The impact of long-duration spaceflight on the horizontal Vestibulo-Ocular Reflex (hVOR) as a measure of the semicircular canals function
- Paper number
IAC-22,B3,8,12,x71054
- Author
Mrs. Chloë De Laet, Belgium, University of Antwerp
- Coauthor
Prof. Ludmila Kornilova, Russian Federation, Institute of Biomedical Problems (IBMP), Russian Academy of Sciences (RAS)
- Coauthor
Mr. Dmitrii Glukhikh, Russian Federation, Institute of Biomedical Problems (IBMP), Russian Academy of Sciences (RAS)
- Coauthor
Mrs. Catho Schoenmaekers, Belgium, University of Antwerp
- Coauthor
Dr. Hamish MacDougall, Australia, The University of Sydney
- Coauthor
Prof. Steven Moore, Australia, Central Queensland University
- Coauthor
Dr. Ivan Naumov, Russian Federation, Institute for Biomedical Problems
- Coauthor
Mr. Leander Wille, Belgium, University of Antwerp
- Coauthor
Dr. Steven Jillings, Belgium, University of Antwerp
- Coauthor
Prof.Dr. Floris Wuyts, Belgium, University of Antwerp
- Year
2022
- Abstract
INTRODUCTION The Semi-Circular Canals (SCCs) and the Otoliths are the two main organs of the vestibular system responsible for balance and gaze-stabilization. Weightlessness impacts the otolith organs, the main gravity detectors. However, as the SCCs are not gravity-dependent, the vestibulo-ocular reflex (VOR) generated by the SCCs is not expected to be affected by a prolonged stay in microgravity. Despite the number of studies that have tried to reveal the effect of microgravity on the SCCs through VOR measurements in the past decades, most of those studies were strongly limited by a restricted sample size and short-duration missions. This study aims to characterize the hVOR changes before and after a long duration spaceflight ($>$6 months) in an unprecedently large cohort of 44 pre- and post-flight vestibular measurements in cosmonauts. MATERIAL AND METHODS 44 pre- and post-flight measurements were performed, of which 13 were from first time flyers (1F group) and 31 were from frequent flyers (FF, N=31), by exposing cosmonauts to off-axis centrifugation before and after their 6-month space mission to the ISS. This study was conducted between ISS expedition 16 (2007) and ISS expedition 61 (2020). Measurements were done approximately two months preflight, three days after landing (Early postflight R+3) and nine days after landing (Late postflight R+9). The hVOR induced by the Visual and Vestibular Investigation System (VVIS) mini centrifuge was assessed and recorded with infrared googles during a 30-second acceleration phase until the maximum velocity of 254°/s was reached. Extraction of nystagmi and associated computations of Slow-Phase Velocity (SPV) and Time Constant (Tc) were made using a custom MatLab routine. The Time Constant of hVOR was then further statistically analyzed in JMP®, using linear mixed-models with p$<$0.05 as significance threshold. RESULTS We found a significant decrease in hVOR time constant Early postflight (R+3) and Late postflight (R+9) compared to preflight. A partial but incomplete recovery was seen nine days after the return of the cosmonauts (Late postflight R+9). CONCLUSION For the first time, our large sample size allowed us to reveal a significant effect of spaceflight on the hVOR. The time constant values measured in cosmonauts are in the physiological range. These findings show an interaction between the otoliths and the canals. Our hypothesis is that the effect shown after spaceflight on both the otolith and the canals are centrally mediated rather than peripheral.
- Abstract document
- Manuscript document
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