Construction Plan of Small Drop Tower and Diffusion Flame Sythesis of Carbon Nanotubes under Microgravity
- Paper number
IAC-04-J.2.03
- Author
Mr. Hiroyuki Ito, Hokkaido University, Japan
- Year
2004
- Abstract
This paper introduces and validates a novel algorithm to continuously estimate changes of total peripheral resistance (TPR) by using peripheral arterial blood pressure (ABP) waveforms. TPR is an important cardiovascular index to monitor, because low TPR is believed to be an indicator of astronauts’ post-flight orthostatic intolerance. In estimating changes of TPR, our algorithm uses diastolic, rather than systolic, ABP values. The hypothesis is that the diastolic pressure values are not influenced by systolic waveform distortion caused by tapered vascular paths, which indicates that use of end-diastolic ABP values would increase TPR estimation accuracy. Our algorithm first calculates the Windkessel time constant which governs diastolic decay in peripheral ABP in such a way that computed and measured ABP waveforms have agreement in diastolic pressure values. Then, TPR, proportional to the Windkessel time constant, is given on a beat-to-beat basis. To validate our algorithm, previously recorded Yorkshire swine data sets were processed and analyzed. An overall root-mean square normalized error of 16.9% was achieved. Our algorithm demonstrated continuous monitoring of TPR changes from peripheral ABP, and has the potential to predict post-flight orthostatic intolerance of astronauts.
- Abstract document
- Manuscript document
IAC-04-J.2.03.pdf (🔒 authorized access only).
To get the manuscript, please contact IAF Secretariat.