The effects of a novel ‘fluid-loading’ strategy combining creatine and glycerol on fluid retention and distribution in humans
- Paper number
IAC-06-A1.P.1.05
- Author
Mr. Chris Easton, University of Glasgow, United Kingdom
- Coauthor
Dr. Alyson Calder, United Kingdom
- Coauthor
Mr. David Kingsmore, United Kingdom
- Coauthor
Dr. Yannis Pitsiladis, University of Glasgow, United Kingdom
- Year
2006
- Abstract
Microgravity is associated with a 10-15% reduction in extracelluar water (ECW) and plasma volume that results in a reduced thermoregulatory capacity during space flight and both exercise capacity and orthostatic intolerance post-space travel (Lane & Feeback, Nutrition 18: 820-828, 2002). Both glycerol (Gly) and creatine (Cr) have been shown to retain modest amounts of fluid when either is consumed with a bolus of water (e.g. Lyons et al. Med Sci Sports Exerc 22: 77-83, 1990; Kilduff et al. Int J Sport Nutr Exerc Metab 14: 443-60, 2004). PURPOSE: To examine the effects of a ’fluid-loading’ strategy that combines Cr and Gly supplementation on fluid retention and distribution. METHODS: Three seven-day Cr and Gly loading protocols (LP) were examined: LPT1: 10 g Cr and 75 g of glucose made up in 1 litre (L) of water (x 2 daily) and a bolus of 1 g Gly/kg body mass (BM) 2.5 hours prior to assessment ( n=6); LP2: 10 g Cr, 1 g Gly/kg BM and 75 g of glucose in 1 L of water (x 2 daily) and final supplement consumed 2.5 hours prior to assessment ( n=6); and LP3: similar to LP2 but final supplement consumed 5 hours prior to assessment ( n=23). RESULTS: Post LP1, BM increased (mean ± s.d.) by 1.59 ± 0.21 kg ( P<0.01) but there was no significant increase in total body water (TBW) (0.31 ± 0.13 L, P=0.53). Post LP2, BM increased by 1.20 ± 0.37 kg ( P<0.01) with no change in TBW (0.15 ± 0.11 L, P=0.71) and a non-significant decrease in ECW (0.22 ± 0.10 L, P=0.13). Post LP3, BM increased by 0.97 ± 0.28 kg ( P<0.01) and TBW increased by 0.87 ± 0.21 L ( P<0.01) with significant increases in both ECW (0.46 ± 0.09 L, P<0.01) and intracellular water (ICW) (0.41 ± 0.21 L, P<0.01). LP3 also appeared to result in a significant haemodilution as indicated by the lower [haemoglobin] and percent haematocrit post-loading. CONCLUSIONS: This novel ’fluid-loading’ strategy combining Cr and Gly resulted in significant increases in all body water compartments (i.e. TBW, ECW and ICW). Further research is planned to examine the effects of this fluid-loading strategy on the cardiovascular response to postural change in normal and deconditioned subjects. Supported by Iovate Health Sciences Research Inc, Canada.
- Abstract document
- Manuscript document
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