LONG – TERM EXPOSURE OF MONKEYS MODELING RADIATION IMPACT DURING MARS MISSION (Gamma – Breeze project)
- Paper number
IAC-08.A1.4.9
- Author
Ph. D. Vladislav Petrov, Institute for Biomedical Problems, Russia
- Year
2008
- Abstract
For ensuring radiation safety of the Mars mission crew from the combination of chronic and acute exposure a calculation model for projecting an in-flight radiation risk should by developed. The model should include probability of a radiation disease appearance depending on a total dose, decrease of work capacity induced by acute reactions, possible decrease of general fixity to the influence of space flight factors. All these data can be obtained in a ground experiment. Such an experiment for long – term exposure modeling radiation impact during the Mars mission is planned. It is called “Gamma breeze. The goals of the experiment are as follows: study of radiobiological reactions of the main regulation systems (nervous, endocrine, immune, cardiovascular, blood forming); investigation of spermatogenesis and cytogenetic response to the radiation exposure; analysis of the delayed effects of exposure (life span, carcinogenesis); estimation of an in-flight radiation risk with taking into account the obtained experimental data. The object of investigation is macaque - mulatt? monkeys, males, age of 3 – 5 years, divided into two groups of 10 – 15 monkeys. Scheme of a radiation impact was chosen in the form similar to real radiation exposure during the Mars mission: combination of chronic and acute exposure. The scheme of exposure is based on modeling maximal unfavorable radiation conditions during the flight of 540 days duration. For modeling the radiation impact the Cs137 source was chosen. The week exposure modeling a galactic cosmic rays’ chronic impact during the flight is equal to 10 mSv, annual dose is 0.5 Sv and chronic dose per experiment is 0.75 Sv. Exposure modeling the acute exposure of solar particle events: at the end of the first quarter of experiment is 0.5 Sv, at the end of the second quarter of experiment – 0.5 Sv, at the end of the fifth quarter of experiment – 1.0 Sv. The total dose per the experiment is equal to 2.75 Sv. During the experiment the following characteristics will be registered: higher nervous activities (with the usage of a computerized method of forming a complex of conditional reflexes and performing the neuro - chemical analysis); hematological, immunological, cytogenetic, and homeostatic reactions; investigation of a cardiovascular system with the usage of a functional loading (head-up-tail and overloads). The results of the analysis of the obtained data will be used for calculating an additional radiation risk caused by a radiation impact.
- Abstract document
- Manuscript document
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