Space Radiation-Induced Cytogenetic Damage in the Blood Lymphocytes of Astronauts
- Paper number
IAC-08.A1.4.10
- Author
Ms. Kerry George, United States
- Coauthor
Dr. Francis A. Cucinotta, National Aeronautics and Space Administration (NASA), United States
- Year
2008
- Abstract
Cytogenetic analysis of astronauts’ blood lymphocytes provides a direct in vivo measurement of space radiation damage that takes into account individual radiosensitivity and considers the influence of microgravity and other stress conditions. We present our latest analyses of chromosome damage in astronauts’ blood lymphocytes assessed by fluorescence in situ hybridization (FISH) chromosome painting and collected at various times, from directly after return from space to several years after flight. Dose was derived from frequencies of chromosome exchanges using preflight calibration curves, and the relative biological effect (RBE) was estimated by comparison with individually measured physically absorbed doses. Values for average RBE were compared to the average quality factor (Q), derived from direct measurements of the lineal energy spectra using a tissue-equivalent proportional counter (TEPC) and radiation transport codes. Results proved that cytogenetic biodosimetry analyses on blood collected within a week or two of return from space provides a reliable estimate of equivalent radiation dose and risk after protracted exposure to space radiation of a few months or more. However, data collected several months or years after flight suggests that the yield of chromosome translocations may decline with time after the mission, indicating that retrospective doses may be more difficult to estimate. In addition, limited data on multiple flights show a lack of correlation between time in space and translocation yields. Data from one crewmember, who has participated in two separate long-duration space missions and has been followed for over 10 years, provide limited information on the effect of repeat flights and show a possible adaptive response to space radiation exposure.
- Abstract document
- Manuscript document
(absent)