Altered intrinsic functional brain connectivity after first-time exposure to short-term gravitational alterations induced by parabolic flight.

Paper number

IAC-18,A1,2,14,x46548

Author

Dr. Angelique Van Ombergen, Belgium, University of Antwerp

Coauthor

Prof. Floris L. Wuyts, Belgium, University of Antwerp

Coauthor

Dr. Ben Jeurissen, Belgium, University of Antwerp

Coauthor

Prof. Jan Sijbers, Belgium, University of Antwerp

Coauthor

Mr. Floris Vanhevel, Belgium, University of Antwerp

Coauthor

Mr. Steven Jillings, Belgium

Coauthor

Prof. Paul M Parizel, Belgium, University of Antwerp

Coauthor

Prof. Stefan Sunaert, Belgium, KU Leuven – University of Leuven

Coauthor

Prof. Paul H Van de Heyning, Belgium, University of Antwerp

Coauthor

Prof. Vincent Dousset, France, University of Bordeaux

Coauthor

Prof. Steven Laureys, Belgium, University of Liège

Coauthor

Dr. Athena Demertzi, Belgium

Year

2018

Abstract

Spaceflight severely impacts the human body. However, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between normal, hyper- and microgravity induced by a parabolic flight (PF) and measured functional MRI connectivity changes. Scans were acquired before and after the PF. To mitigate motion sickness, PF participants received scopolamine prior to PF. To account for the scopolamine effects, 12 non-PF controls were scanned prior to and after scopolamine injection. Changes in functional connectivity
were explored with the Intrinsic Connectivity Contrast (ICC). Seed-based analysis on the regions exhibiting localized changes was subsequently performed to understand the networks associated with the identified nodes. We found that the PF group was characterized by lower ICC scores in the right temporo-parietal junction (rTPJ), an area involved in multisensory integration and spatial tasks. The encompassed network revealed PF-related decreases in within- and inter-hemispheric anticorrelations between the rTPJ and the supramarginal gyri, indicating both altered vestibular and
self-related functions. Our findings shed light on how the brain copes with gravity transitions, on gravity internalization and are relevant for the understanding of bodily self-consciousness

Abstract document

IAC-18,A1,2,14,x46548.brief.pdf

Manuscript document

IAC-18,A1,2,14,x46548.pdf (🔒 authorized access only).

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