Cytogenetic Investigations Of Nucleus-containing Marrow Cells After Chronic Combined Exposure To Low-intensity Chemical And Radiation Factors Inherent To The Environment Of Pilots’ Space Vehicles
- Paper number
IAC-07-A1.5.-A1.7.07
- Author
Ms. Mary Barantzeva, Institute for Biomedical Problems, Russia
- Coauthor
Ms. Lana Mukhamedieva, Institute for Biomedical Problems, Russia
- Coauthor
Mr. Boris Fedorenko, Russia
- Coauthor
Ms. Svetlana Vorozhtsova, Institute for Biomedical Problems, Russia
- Year
2007
- Abstract
Subject of the investigation was cytogenetic changes in marrow karyocytes of laboratory animals after combined exposure to chemical and radiation factors inherent to the environment of piloted space vehicles. The experiments were performed with 300 male mice F1 with the body mass of 20-23 grams. Thirty-day exposure to a chemical mixture was followed by 30-day gamma-irradiation at a total dose of 30 cGy. Chromosomal aberrations {bridges and fragments} were counted in nucleus-containing marrow cells. Chromosomal aberrations in nucleus-containing marrow cells of mice were found qualitatively and quantitatively different depending on one-factor or combined exposure. The combined exposure {chemical mixture and radiation} increases the frequency of chromosomal aberrations largely due to fragments {91.2%} which is similar to the outcome of chemical exposure alone {96.4%} and points to domination of the chemical factors. Low doses of ionizing radiation produced prevailing chromosomal aberrations with a prevalence of bridges {66.7%}. The reparative processes in the marrow were less intensive following the exposure to the combination of radiation and chemical mixture as compared to exposure of either of the factors. It was demonstrated that the dose-effect ratio in case of low doses of ionizing irradiation or the chemical-radiation exposure is not linear. Based on the results of the investigation, chronic low-intensity chemical-radiation exposure causes more severe chromosomal damages in the marrow cell of mice when compared with these effects of chemical and radiation factors alone. Analysis of cytogenetic damages of the marrow karyocytes evidenced the dominating effect from the chemical factor in the situation of combined exposure to chemical mixture and radiation
- Abstract document
- Manuscript document
IAC-07-A1.5.-A1.7.07.pdf (🔒 authorized access only).
To get the manuscript, please contact IAF Secretariat.