Three-Dimensional Model of Tissue and Heavy Ions Effects
- Paper number
IAC-07-A1.9.-A2.7.03
- Author
Dr. Alamelu Sundaresan, Texas Southern University, United States
- Coauthor
Dr. Francis Cucinotta, National Aeronautics and Space Administration (NASA)/Johnson Space Center, United States
- Coauthor
Dr. Artem Ponomarev, Universities Space Research Association, United States
- Year
2007
- Abstract
A three-dimensional tissue model was incorporated into a new Monte Carlo algorithm that simulates passage of heavy ions in a ‘tissue box’. The tissue box was given as a realistic model of tissue based on confocal microscopy images. The action of heavy ions on the cellular matrix for 2- or 3-dimensional cases was simulated. Cells were modeled as a cell culture monolayer in one example, where the data were taken directly from microscopy (2-d cell matrix), and as a multi-layer obtained from confocal microscopy (3-d case). Image segmentation was used to identify cells with precise areas/volumes in an irradiated cell culture monolayer, and slices of tissue with many cell layers. The cells were then inserted into the model box of the simulated physical space pixel by pixel. In the case of modeled tissues (3-d), the tissue box had periodic boundary conditions imposed, which extrapolates the technique to macroscopic volumes of tissue. For the real tissue (3-d), specific spatial patterns for cell apoptosis and necrosis are expected. The cell patterns were modeled based on action cross sections for apoptosis and necrosis estimated from current experimental data. A spatial correlation function indicating a higher spatial concentration of damaged cells from heavy ions relative to the low-LET radiation cell damage pattern is presented.
- Abstract document
- Manuscript document
IAC-07-A1.9.-A2.7.03.pdf (🔒 authorized access only).
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